Virginiamycin M1; Mikamycin A; NSC 244426; NSC 87432; Pristinamycin IIA; RP 12536; Streptogramin A
21411-53-0
525.6
C28H35N3O7
DMF, DMSO. Slightly soluble in ethanol, methanol.
-20°C
Ostreogrycin A is the major component of the virginiamycin complex. In the 1950s this complex was independently discovered so many times that the literature became highly confusing. Ostreogrycin A is a macrocyclic lactone antibiotic that acts synergistically with the structurally unrelated cyclic depsipeptides, virginiamycin B (ostreogrycin B, streptogramin B) and virginiamycin S, to inhibit peptide elongation. This is achieved by blocking formation of a peptide bond between the growing peptide chain (peptidyl-tRNA) linked to the 50S ribosome and aminoacyl-tRNA. Ostreogrycin A is highly active against Gram positive bacteria, particularly MRSA.
0.1 lbs
Research or further manufacturing use only, not for food or drug use.
